Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice (Small 38/2024)

Controlling Gene Expression In article number 2311834, Wilfried Weber and co‐workers demonstrate that the material properties of transcription factor condensates impact their activity on target promoters. While liquid (spherical) condensates induce increased transcriptional activity, gel‐like (non‐s...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-09, Vol.20 (38), p.n/a
Hauptverfasser:	Fischer, Alexandra A.M., Robertson, Hanah B., Kong, Deqiang, Grimm, Merlin M., Grether, Jakob, Groth, Johanna, Baltes, Carsten, Fliegauf, Manfred, Lautenschläger, Franziska, Grimbacher, Bodo, Ye, Haifeng, Helms, Volkhard, Weber, Wilfried
Format:	Artikel
Sprache:	eng
Schlagworte:	biomolecular condensates liquid‐liquid phase separation material properties of protein condensates optogenetics synthetic biology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Controlling Gene Expression In article number 2311834, Wilfried Weber and co‐workers demonstrate that the material properties of transcription factor condensates impact their activity on target promoters. While liquid (spherical) condensates induce increased transcriptional activity, gel‐like (non‐spherical) condensates correlate with strongly decreased gene expression.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.202470280