[Cell@Al2O3(HEPiPY)]DCA: A Cellulose Supported Ionic Liquid Catalyst for Synthesis of 11 b,12‐dihydro‐6H,13Hbenzo[5,6][1,3]oxazino[3,4‐a]quinazoline‐6,13‐dione along with in silico assessments

In present study we have designed and synthesized novel cellulose supported ionic liquid catalyst (CSILC), [Cell@Al2O3(HEPiPY)]DCA and explored its catalytic efficiency for synthesis of novel 11b,12‐dihydro‐6H,13Hbenzo[5,6][1,3]oxazino[3,4‐a]quinazoline‐6,13‐diones by performing the one pot reaction of 2‐(2‐hydroxyaryl)‐2,3‐ dihydroquinazolin‐4(1H)‐one and 1,1‐carbonyl diimidazole (CDI). The catalyst was characterized by diverse analytical techniques viz. Fourier‐Transform Infrared Spectroscopy (FT‐IR), Scanning Electron Microscopy (SEM), Energy Dispersive X‐ray Analysis (EDX) and Thermo Gravimetric Analysis (TGA). The biological activities of synthesized novel derivatives were evaluated along with in silico assessments against the vascular endothelial growth factor receptor‐2 (VEGFR‐2) target, in which the results were considerable. The catalyst exhibited remarkable reusability up to six consecutive runs without considerable loss in the catalytic activity. A highly efficient cellulose supported ionic liquid catalyst, Cell@Al2O3(HEPiPY)]DCA have been synthesized, and well characterized by IR, SEM, EDX, TGA techniques. The catalyst remarkably employed for synthesis of 11b,12‐dihydro‐6H,13Hbenzo[5,6][1,3]oxazino[3,4‐a]quinazoline‐6,13‐dione derivatives. The activity of synthesized derivatives was examined by performing their in silico assessment resulting considerable results.