Direct Synthesis of Methylene‐Bridged Bis‐biaryl Carboxylates via Cascade Suzuki Coupling and CH2Cl2‐Based Bis‐esterification

The multicomponent reactions of iodobenzoic acids, aryl boronic acids, and dichloromethane (DCM) have been designed for the synthesis of various methylene‐bridged bis‐biaryl functionalized carboxylates. Under the catalysis of Pd(OAc)2, the formation of the products involves the cascade Suzuki coupling and CH2Cl2‐base bis‐esterification. The present work offers a direct and practical route to the synthesis of novel carboxylate scaffolds with extended diversity. The multicomponent reactions of iodobenzoic acids, aryl boronic acids and dichloromethane are developed for the synthesis of methylene‐bridged bis‐biaryl carboxylates. The synthesis of the products is achieved via tandem Suzuki coupling and DCM‐based double etherification.