In vitro characterization of an Fe8 cluster as potential MRI contrast agent

In vitro characterization of an Fe8 cluster as potential MRI contrast agent

The complex [(tacn)6Fe8(µ3‐O)2(µ2‐OH)12]Br8·9H2O (Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd‐DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd‐DTPA at h...

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Veröffentlicht in:NMR in biomedicine 2005-08, Vol.18 (5), p.300-307
Hauptverfasser: Rodríguez, Elisenda, Roig, Anna, Molins, Elies, Arús, Carles, Quintero, María Rosa, Cabañas, Miquel E., Cerdán, Sebastián, Lopez-Larrubia, Pilar, Sanfeliu, Coral
Format: Artikel
Sprache:eng
Schlagworte:
contrast agent
Fe8
Magnetic resonance imaging
molecular magnets
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Zusammenfassung:The complex [(tacn)6Fe8(µ3‐O)2(µ2‐OH)12]Br8·9H2O (Fe8) was evaluated in vitro as a new kind of possible MRI contrast agent. Relaxivities were measured at 1.41 and 9.4 T for Fe8 and commercial Gd‐DTPA dissolved in PBS. There was significant difference for r1 and r2 values between Fe8 and Gd‐DTPA at high field (9.4 T) and for r1 at low field (1.4 T) (p
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.959