Back Cover: Gene Expression Profiling of 1α,25(OH)2D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic‐Metabolizing Genes

Mol. Nutr. Food Res. 2022, 66, 202200070 DOI: 10.1002/mnfr.202200070 Few enzymes providing drug clearance are found under the control of activated vitamin D receptor (VDR) in the liver. In article number 2200070, Petr Pavek and co‐workers investigate whether active vitamin D3 regulates major detoxif...

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Veröffentlicht in:Molecular nutrition & food research 2022-05, Vol.66 (9), p.n/a
Hauptverfasser: Pavek, Petr, Dusek, Jan, Smutny, Tomas, Lochman, Lukas, Kucera, Radim, Skoda, Josef, Smutna, Lucie, Kamaraj, Rajamanikkam, Soucek, Pavel, Vrzal, Radim, Dvorak, Zdenek
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Sprache:eng
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Zusammenfassung:Mol. Nutr. Food Res. 2022, 66, 202200070 DOI: 10.1002/mnfr.202200070 Few enzymes providing drug clearance are found under the control of activated vitamin D receptor (VDR) in the liver. In article number 2200070, Petr Pavek and co‐workers investigate whether active vitamin D3 regulates major detoxification enzymes and transporters in 2D and 3D cultures of human hepatocytes. They show that VDR or vitamin D supplementation is unlikely to significantly influence drug elimination.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.202270027