Investigation of Machilus macrantha Nees. II : Pharmacological Action and Chemical Constitution of Machiline

Machiline, isolated as the hydrochloride from the root of Machilus macrantha Nees., has been studied for its pharmacological action and chemical characteristics. It has been found to lower blood pressure of experimental animals by a direct depressant effect on the myocardium. It has no antibacterial activity. A number of derivatives have been prepared. Based on the results of (a) microanalysis for elements of the base, its hydrochloride, picrate, acetyl, and benzoyl derivatives, (b) chemical tests for functional groups, (c) microestimation of —OCH3 in the base and =NCH3 in the methiodide, and (d) infrared and ultraviolet absorption spectra, two structures are proposed for machiline