An Evaluation of Certain Hypotensive Agents IV. : Diquaternarized piperidine derivatives

An Evaluation of Certain Hypotensive Agents IV. : Diquaternarized piperidine derivatives

Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and...

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1960-09, Vol.49 (9), p.586-589
Hauptverfasser: Buckley, J.P., Jacquart, M.L., Bianculli, J.A., Bickerton, R.K., Hudak, W.J., Schalit, F.M., Defeo, J.J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Certain diquaternarized piperidine derivatives and several bis-tertiary amines were evaluated in the anesthetized rat and dog. The most active hypotensive agents were: 3-mor-pholinopropyl N-methylpipecolinate di-methiodide (JB-643), 2-morpholinoethyl N-methylpipecolinate dimethobromide (JB-654), and beta (3-diethylamino-1-propynyl)-N-methylpiperidine dimethobromide (JB-579). The compounds JB-643 and JB-654, administered orally to unanesthetized dogs, produced marked hypotensive responses persisting for more than eleven hours.
ISSN:0095-9553
1930-2304
DOI:10.1002/jps.3030490907