A Study of Certain Analgetic-Antipyretic Compounds
Two new compounds, α-phenyl-α-(2-piperi-dino-ethyl)-β-ethyl-butyric acid nitrile and 1 - phenyl - 2,3 - dimethyl - 4 - (phenyl-methyl-morpholino) - methyl - pyrazolone-(5), have been studied by various procedures. These compounds showed no analgetic activity by a thermal method in mice, weak analget...
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| Veröffentlicht in: | Journal of the American Pharmaceutical Association (Scientific ed.) 1960-05, Vol.49 (5), p.298-301 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Two new compounds, α-phenyl-α-(2-piperi-dino-ethyl)-β-ethyl-butyric acid nitrile and 1 - phenyl - 2,3 - dimethyl - 4 - (phenyl-methyl-morpholino) - methyl - pyrazolone-(5), have been studied by various procedures. These compounds showed no analgetic activity by a thermal method in mice, weak analgetic activity as indicated by blockade of irritant-induced writhing in mice, good antipyretic activity in rats, and no antigranulomatous activity in rats. |
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| ISSN: | 0095-9553 1930-2304 |
| DOI: | 10.1002/jps.3030490511 |