A Study Of the Effect of Some Emulsifying Agents on Drug Release from Suppository Bases

A Study Of the Effect of Some Emulsifying Agents on Drug Release from Suppository Bases

Suppositories consisting of varying amounts of hydrogenated cottonseed oil, Tweens, Sans, and Arlacels were incorporated with a dye and tested for the percentage of dye release at time intervals. Most of the suppositories were tested for storage qualities and seven were subjected to in vivo tests. S...

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Veröffentlicht in:Journal of the American Pharmaceutical Association (Scientific ed.) 1959-06, Vol.48 (6), p.353-355
Hauptverfasser: Whitworth, Clyde W., Larocca, Joseph P.
Format: Artikel
Sprache:eng
Schlagworte:
Drug Liberation
Emulsifying Agents
Emulsions
Pharmaceutical Preparations
Polyethylene Glycols
Suppositories
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Zusammenfassung:Suppositories consisting of varying amounts of hydrogenated cottonseed oil, Tweens, Sans, and Arlacels were incorporated with a dye and tested for the percentage of dye release at time intervals. Most of the suppositories were tested for storage qualities and seven were subjected to in vivo tests. Several of the proposed bases appear to be very promising and compare favorably in vivo with a commercial brand of suppository now being widely used.
ISSN:0095-9553
1930-2304
DOI:10.1002/jps.3030480615