An Evaluation of Certain Hypotensive Agents II : Acetylenic Bis-Onium Derivatives

A series of nine new bis-quaternary and three bis-tertiary ammonium compounds were screened and evaluated for their hypotensive activity in rats. Further studies were conducted on dogs. It was found that there was a definite qualitative correlation between the responses in rats and dogs. Pentolinium bitartrate and chlorisondamine dimethochloride were utilized as standards in the rat evaluation studies. The most promising of the experimental compounds were 1,5-bis(diethylamino)-2-pentyne dimethobromide, 1,6-bis(morpholino)-2-hexyne dimethobromide, and 1,6-bis(pyrrolidino)-3-hexyne dimethobromide.