Sulfaethylthiadiazole I. : Interpretations of Human Blood Level Concentrations Following Oral Doses

Blood concentration studies were conducted for a ten or twelve hour period on eleven human subjects receiving sulfaethylthiadiazole orally in 1-4-Gm. doses. The drug disappearance rate from the blood was characterized as approximately first-order, from which the standard performance indices (kb)kb, (t1/2)b and Co were determined. This approach to characterization of drug disappearance rates from the blood also permitted a close estimation of the per cent of total drug in the blood which existed in the biotransformed state. For this type of drug it is suggested that the methods of analysis presented can furnish useful scientific criteria for better evaluation of drug performance, and that in industrial pharmacy it can guide the pharmaceutical project team in formulation and establishment of dosage schedules.