In vitro adsorption of doxorubiein hydroehloride on insoluble calcium phosphate

The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate were established. Tribasic calcium phosphate was chosen as a mod...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1977-09, Vol.66 (9), p.1346-1347
Hauptverfasser:	Sturgeon, Roy J., Flanagan, Cynthia, Naik, Datta V., Schulman, Stephen G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption-doxorubicin hydrochloride on solid tribasic calcium phosphate in vitro Calcium phosphate Calcium phosphate, tribasic—adsorption of doxorubicin hydrochloride in vitro Doxorubicin hydrochloride-adsorption on solid tribasic calcium phosphate in uitro tribasic-adsorption of doxorubicin hydrochloride in vitro
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Zusammenfassung:	The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate were established. Tribasic calcium phosphate was chosen as a model for solid bone samples, which are stained with doxorubicin in patients who have received long‐term doxorubicin therapy.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600660940