5-fluorouracil and derivatives in cancer chemotherapy III: in vivo enhancement of antitumor activity of 5-fluorouracil (fu) and 5-fluoro-2′-deoxyuridine (fudr)

The antitumor activity of 5‐fluorouracil (FU) and 5‐fluoro‐2′‐deoxyuridine (FUDR) has been enhanced in mice in the presence of deoxyribose donors such as 2′‐deoxyuridine (UDR). Based upon in vitro data, it appears that the enhancement is due to the conversion of 5‐fluorouracil to 5‐fluoro‐2′‐deoxyur...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1973-12, Vol.62 (12), p.1975-1978
Hauptverfasser:	Jato, Johnson, Windheuser, J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluoro-2′-deoxyuridine (FUDR)-antitumor activity enhanced by deoxyribose donors (2′-deoxyuridine) 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FUDR)-enhanced in presence of deoxyribose donors (2′-deoxyuridine) 5-Fluorouracil (FU)-antitumor activity enhanced by deoxyribose donors (2′-deoxyuridine) 5‐Fluorouracil (FU)—antitumor activity enhanced by deoxyribose donors (2′‐deoxyuridine), mice 5‐Fluoro‐2′‐deoxyuridine (FUDR)—antitumor activity enhanced by deoxyribose donors (2′‐deoxyuridine), mice Antitumor activity Antitumor activity, 5‐fluorouracil (FU) and 5‐fluoro‐2′‐deoxyuridine (FUDR)—enhanced in presence of deoxyribose donors (2′‐deoxyuridine), mice Cancer chemotherapy-enhancement of 5-fluorouracil (FU) and 5-fluoro-2′-deoxyuridine (FUDR) activity by deoxyribose donors (2′-deoxyuridine) Cancer chemotherapy—enhancement of 5‐fluorouracil (FU) and 5‐fluoro‐2′‐deoxyuridine (FUDR) activity by deoxyribose donors (2′‐deoxyuridine), mice mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The antitumor activity of 5‐fluorouracil (FU) and 5‐fluoro‐2′‐deoxyuridine (FUDR) has been enhanced in mice in the presence of deoxyribose donors such as 2′‐deoxyuridine (UDR). Based upon in vitro data, it appears that the enhancement is due to the conversion of 5‐fluorouracil to 5‐fluoro‐2′‐deoxyuridine in blood and the stabilization of 5‐fluoro‐2′‐deoxyuridine due to the presence of 2′‐deoxyuridine.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600621215