Preparation of 213bi-dota-biotin in high specific activity for pretargeted alpha radiotherapy of cancer

Preparation of 213bi-dota-biotin in high specific activity for pretargeted alpha radiotherapy of cancer

The alpha emitter, Bismuth‐213, (213Bi) T1/2 = 45 min, obtained from an 225Ac generator, was chelated to DOTA‐biotin in high radiochemical yield and specific activity. The radiolabeled product showed good radiochemical stability and was used in preclinical therapy studies using a pretargeting format...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 2001-05, Vol.44 (S1), p.S726-S728
Hauptverfasser: Hylarides, Mark D., Axworthy, Don B., Fritzberg, Alan R.
Format: Artikel
Sprache:eng
Schlagworte:
alpha emitters
Bismuth-213
DOTA-biotin
pretargeting
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Beschreibung
Zusammenfassung:The alpha emitter, Bismuth‐213, (213Bi) T1/2 = 45 min, obtained from an 225Ac generator, was chelated to DOTA‐biotin in high radiochemical yield and specific activity. The radiolabeled product showed good radiochemical stability and was used in preclinical therapy studies using a pretargeting format.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.25804401256