Syntheses of di-tritiated 9(O)-methano-Δ6(9α)-prostaglandin I1 methyl esters

Two di‐tritiated isocarbacyclin [9(O)‐methano‐Δ6(9α)‐prostaglandin I1] methyl esters 5, 10 were synthesized from (Z)‐olefinic precursors 23, 31 at ω‐side chain by catalytic hydrogenation with tritium gas, respectively. These substances 5, 10 having high specific activities can be used for the pharma...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1991-10, Vol.29 (10), p.1107-1119
Hauptverfasser:	Manabe, Kenji, Tanaka, Toshio, Kurozumi, Seizi, Kato, Yoshinori
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	(17S)-17 (17S)‐17,20‐dimethylisocarbacyclin‐[3H2] 20-dimethylisocarbacyclin-[3H2] 9(O)-methano-Δ6(9α)-prostaglandin I1-[3H2] isocarbacyclin-[3H2]
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Beschreibung
Zusammenfassung:	Two di‐tritiated isocarbacyclin [9(O)‐methano‐Δ6(9α)‐prostaglandin I1] methyl esters 5, 10 were synthesized from (Z)‐olefinic precursors 23, 31 at ω‐side chain by catalytic hydrogenation with tritium gas, respectively. These substances 5, 10 having high specific activities can be used for the pharmacokinetics and metabolism studies of 9(O)‐methano‐Δ6(9α)‐prostaglandin I1 methyl ester 2 and its (17S)‐17,20‐dimethyl derivatives 7.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/jlcr.2580291003