Synthesis of 14C-radiolabelled tilmicosin

Synthesis of 14C-radiolabelled tilmicosin

Tilmicosin was radiolabelled with carbon‐14 on the 3,5‐dimethylpiperidinyl sidechain as a requirement for animal metabolism studies. A new radiosynthesis of 3,5‐dimethyl‐piperidine was developed for this purpose. Incorporation into the desmycosin nucleus was accomplished by a reductive amination rea...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1989-04, Vol.27 (4), p.465-471
Hauptverfasser: Crouse, Gary D., Terando, Norman H.
Format: Artikel
Sprache:eng
Schlagworte:
14C
3,5‐dimethylpiperidine
5-dimethylpiperidine
radiolabelled
reductive amination
side-chain
Tilmicosin
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Zusammenfassung:Tilmicosin was radiolabelled with carbon‐14 on the 3,5‐dimethylpiperidinyl sidechain as a requirement for animal metabolism studies. A new radiosynthesis of 3,5‐dimethyl‐piperidine was developed for this purpose. Incorporation into the desmycosin nucleus was accomplished by a reductive amination reaction.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580270414