A new method for labelling 11β-hydroxy steroids: Synthesis of 18-2H-corticosteroids

A new method for labelling 11β-hydroxy steroids: Synthesis of 18-2H-corticosteroids

A new method for labelling 11β‐hydroxy steroids is described. The procedure involves specifically placing the label on the angular C13 methyl group via the photolysis of the 11β‐nitrite ester (Barton reaction) and reaction of the resulting C18 radical with PhS‐2H in situ. Incorporations of 2H were 3...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1980-11, Vol.17 (6), p.911-919
Hauptverfasser: Green, Michael J., Shue, Ho-Jane, Bartner, Peter, Morton, James B., Youngstrom, Richard E., Meinwald, Jerrold
Format: Artikel
Sprache:eng
Schlagworte:
18-2H-Corticosteroids
Barton Reaction
Phenylthiol
Photolysis
Radical Trapping
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Zusammenfassung:A new method for labelling 11β‐hydroxy steroids is described. The procedure involves specifically placing the label on the angular C13 methyl group via the photolysis of the 11β‐nitrite ester (Barton reaction) and reaction of the resulting C18 radical with PhS‐2H in situ. Incorporations of 2H were 30‐40% for 9α‐H, 12‐21% for 9α‐F and
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580170617