Labeled metabolites of polycyclic aromatic hydrocarbons. VI. Trans-7,8-dihydrobenzo[a]pyrene-7,8,diol-G-3H and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-G-3H

Labeled metabolites of polycyclic aromatic hydrocarbons. VI. Trans-7,8-dihydrobenzo[a]pyrene-7,8,diol-G-3H and (±)-7α,8β-dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-G-3H

The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐3H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐3H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8,9,10‐tetrahydrob...

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1976-10, Vol.12 (4), p.583-589
Hauptverfasser: McCaustland, Daniel J., Fischer, Daniel L., Duncan, W. P., Ogilvie, Edward J., Engel, James F.
Format: Artikel
Sprache:eng
Schlagworte:
(±)-7α 8β-Dihydroxy-9β
10-tetrahydrobenzo[a]pyrene-G3H
10β-epoxy-7
8-Dihydrobenzo[a]pyrene-7
8-diol-G-3H
metabolites
Polycyclic aromatic hydrocarbons
trans-7
trans‐7,8‐Dihydrobenzo[a]pyrene‐7,8‐diol‐G‐3H, (±)‐7α 8β‐Dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G3H
Tritium
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Zusammenfassung:The syntheses of trans‐7,8‐dihydrobenzo[a]pyrene‐7,8‐diol‐G‐3H (V) and (±)‐7α, 8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐G‐3H (VI) are described. The specific activities of V and VI were 158 mCi/mmole and 220 mCi/mmole, respectively. The key intermediate, trans‐7,8,9,10‐tetrahydrobenzo[a]pyrene‐7,8‐diol‐G‐3H dibenzoate (III), was prepared by catalytic dehalogenation with tritium gas.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580120416