New efficient approach for the synthesis of 2-alkyl(aryl) substituted 4H-pyrido[1,2-a]pyrimidin-4-ones

A new, efficient and easy route for the preparation of a series of 2‐alkyl(aryl) substituted 4‐oxo‐4H‐pyrido‐[1,2‐a]pyrimidines, where alkyl = CH3; aryl = C6H5, 4‐FC6H4, 4‐ClC6H4, 4‐BrC6H4, 4‐CH3C6H4, 4‐OCH3C6H4, 4‐NO2C6H4 in 45–80 % yield from the reaction of β‐alkoxyvinyl trichloromethyl ketones with 2‐aminopyridine under mild conditions, is then reported.