Front Cover: Pd0‐Mediated Cross‐Coupling of [11C]Methyl Iodide with Carboxysilane for Synthesis of [11C]Acetic Acid and its Active Esters: 11C‐Acetylation of Small, Medium, and Large Molecules (Eur. J. Org. Chem. 29/2021)

The Front Cover shows a demonstration of 11C‐acetylation radiolabeling of small, medium, and large molecules. A rapid Pd0‐mediated cross‐coupling of radioactive [11C]methyl iodide and carboxytriphenylsilane was developed for synthesis of [2‐11C]acetic acid and its active esters as 11C‐acetylation reagents. The 11C‐acetylated molecules can be used for in vivo PET imaging in the field of life science. More information can be found in the Full Paper by H. Doi et al.