KOt‐Bu‐Catalyzed Chemo‐ and Regioselective Hydroamination of Allylic Sulfones with Indoles

A highly chemo‐ and regioselective KOt‐Bu‐catalyzed addition of substituted indoles to terminal or disubstituted allylic sulfones at the indole N‐position is reported. The catalytic protocol allows for the efficient and mild synthesis of a broad range of new and versatile sulfonyl‐substituted indoles and azoles bearing various functional groups from readily available starting materials in good to excellent yields with complete regioselectivity. A highly chemo‐ and regioselective hydroamination of β,γ‐unsaturated sulfones with indoles using a KOt‐Bu catalyst is described. A series of β‐indolyl sulfones was easily obtained in good to excellent yields under simple and mild reaction conditions.