Synthesis of Tertiary sec-Alkylamines by the Addition of Grignard Reagents to N,N-Dialkylformamides Mediated by Ti(OiPr)4 and Me3SiCl

Synthesis of Tertiary sec-Alkylamines by the Addition of Grignard Reagents to N,N-Dialkylformamides Mediated by Ti(OiPr)4 and Me3SiCl

A number of tertiary sec‐alkylamines (22 examples, 29–80 % yield) have been prepared according to a simple one‐pot procedure by the addition of Grignard reagents to N,N‐dialkylformamides in the presence of Ti(OiPr)4 and Me3SiCl. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)...

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Veröffentlicht in:European Journal of Organic Chemistry 2008-10, Vol.2008 (30), p.5107-5111
Hauptverfasser: Tomashenko, Olesya, Sokolov, Viktor, Tomashevskiy, Alexander, Buchholz, Herwig A., Welz-Biermann, Urs, Chaplinski, Vladimir, de Meijere, Armin
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Grignard ­reagents
Nucleophilic addition
Titanium tetraisopropoxide
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Zusammenfassung:A number of tertiary sec‐alkylamines (22 examples, 29–80 % yield) have been prepared according to a simple one‐pot procedure by the addition of Grignard reagents to N,N‐dialkylformamides in the presence of Ti(OiPr)4 and Me3SiCl. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) Tertiary sec‐alkylamines are obtained from N,N‐dialkylformamides and Grignardreagents in the presence of Ti(OiPr)4 andMe3SiCl.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200800629