Nanozymes of Ni0.5Fe0.5S2 Mediated Synergetic Antitumor Treatment

How to establish a multi‐modality oncotherapy method on the basis of single matter mediated utilization of tumor endogenous substances is very promising for efficient antitumor treatment. In this work, we have designed a metallic Ni0.5Fe0.5S2 nanosphere for synergetic chemodynamic/photodynamic/photothermal antitumor treatments. Under NIR excitation, a remarkable photothermal effect could be generated by Ni0.5Fe0.5S2 for realizing the photothermal therapy. Meanwhile, Ni0.5Fe0.5S2 could also trigger formation of reactive oxygen species (ROS) via transformation of tumor‐site oxygen for the further photodynamic therapy. Furthermore, peroxidase‐like property of Ni0.5Fe0.5S2 favors the catalysis of endogenous H2O2 into hydroxyl radical to achieve a chemodynamic therapy. As a result, the on‐site tumor hyperthermia, tumor‐site oxygen and H2O2 conversion are worked for the antitumor action. On the merits of above synergistic effect, a better antitumor outcome was confirmed as compared with any single antitumor action, and complete removal of solid tumor under a relative lower temperature has been accomplished. Metallic Ni0.5Fe0.5S2 possesses NIR‐driven photothermal and photodynamic effect, as well as peroxidase‐like activity, thus realizing a triple antitumoral effect for in vivo elimination of solid tumor on mice in a biosafe way.