Synthesis, Crystal Structure and in vitro Antitumor Activity of Di-n-butyltin p-[N, N-Bis(2-chloroethyl)amino]benzoates

Di‐n‐butyltin oxide reacted with p‐[N,N‐bis(2‐chloroethyl)amino]benzoic acid to yield the compounds {{4‐[(ClCH2CH2)2N]C6H4COOSnBu2}2O}2 (1) and {4‐[(ClCH2CH2)2N]C6H4COO}2SnBu2 (2), which have been characterized by IR and 1H NMR spectra. The X‐ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n‐butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL‐60 cell lines.