Color Tuning of Fluorogens for FAST Fluorogen‐Activating Protein

Color Tuning of Fluorogens for FAST Fluorogen‐Activating Protein

Using benzylidene imidazolone core, we created a panel of color‐shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live‐cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of...

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Veröffentlicht in:Chemistry : a European journal 2021-02, Vol.27 (12), p.3986-3990
Hauptverfasser: Myasnyanko, Ivan N., Gavrikov, Alexey S., Zaitseva, Snizhana O., Smirnov, Alexander Yu, Zaitseva, Elvira R., Sokolov, Anatolii I., Malyshevskaya, Kseniya K., Baleeva, Nadezhda S., Mishin, Alexander S., Baranov, Mikhail S.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Multidisciplinary
chromophore
Color
fluorescence
Fluorescent Dyes
fluorescent labeling
fluorogen-activating proteins
green fluorescent protein
Labeling
Physical Sciences
Proteins
Science & Technology
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Zusammenfassung:Using benzylidene imidazolone core, we created a panel of color‐shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live‐cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live‐cell fluorogenic labeling tools. A series of color‐shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live‐cell protein labeling are presented. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of live‐cell fluorogenic labeling tools.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202004760