New Insights for Pursuing High Relaxivity MRI Agents from Modelling the Binding Interaction of GdIII Chelates to HSA

Sticking out. This work is aimed at obtaining new insights into the design of novel Gd chelates that form high‐affinity adducts with HSA. Two new GdIII complexes that differ in the size of the hydrophobic moiety responsible for the interaction with the protein have been synthesised. It was shown that the two complexes protrude to a different extent from the surface of the protein (see picture), and this difference has an effect on the exchange of the coordinated water molecule.