Direct Magnesiation of Polyfunctionalized Arenes and Heteroarenes Using (tmp)₂Mg·2 LiCl

Direct Magnesiation of Polyfunctionalized Arenes and Heteroarenes Using (tmp)₂Mg·2 LiCl

Outstripping lithium bases: A wide range of polyfunctional aryl and heteroaryl magnesium reagents were efficiently prepared in THF by direct magnesiation with (tmp)2Mg⋅2 LiCl, an exceptionally active base. These compounds can serve as intermediates in natural product synthesis. In the example shown...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2007-10, Vol.46 (40), p.7681-7684
Hauptverfasser: Clososki, Giuliano C, Rohbogner, Christoph J, Knochel, Paul
Format: Artikel
Sprache:eng
Schlagworte:
copper
cross-coupling
homogeneous catalysis
lithium chloride
organomagnesium compounds
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Outstripping lithium bases: A wide range of polyfunctional aryl and heteroaryl magnesium reagents were efficiently prepared in THF by direct magnesiation with (tmp)2Mg⋅2 LiCl, an exceptionally active base. These compounds can serve as intermediates in natural product synthesis. In the example shown a palladium‐catalyzed cross‐coupling reaction is used to prepare a derivative of salicylic acid.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200701487