Mixed Mg/Li Amides of the Type R2NMgCl⋅LiCl as Highly Efficient Bases for the Regioselective Generation of Functionalized Aryl and Heteroaryl Magnesium Compounds

Mixed Mg/Li Amides of the Type R2NMgCl⋅LiCl as Highly Efficient Bases for the Regioselective Generation of Functionalized Aryl and Heteroaryl Magnesium Compounds

Two are better than one: Mixed lithium‐magnesium complexes of the type R2NMgCl⋅LiCl are kinetically highly active bases that convert a range of polyfunctional aromatic and heteroaromatic substrates into the corresponding magnesiated derivatives with high regioselectivity.

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Veröffentlicht in:Angewandte Chemie International Edition 2006-04, Vol.45 (18), p.2958-2961
Hauptverfasser: Krasovskiy, Arkady, Krasovskaya, Valeria, Knochel, Paul
Format: Artikel
Sprache:eng
Schlagworte:
amides
Ggrignard reagents
heterocycles functionalization
lithium chloride
magnesium amides
mixed bases
regioselective metalation
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Beschreibung
Zusammenfassung:Two are better than one: Mixed lithium‐magnesium complexes of the type R2NMgCl⋅LiCl are kinetically highly active bases that convert a range of polyfunctional aromatic and heteroaromatic substrates into the corresponding magnesiated derivatives with high regioselectivity.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200504024