A Versatile Method for Suzuki Cross‐Coupling Reactions of Nitrogen Heterocycles

A Versatile Method for Suzuki Cross‐Coupling Reactions of Nitrogen Heterocycles

A wide‐ranging study of Suzuki reactions which use nitrogen‐containing heterocycles is described (see scheme; dba=dibenzylideneacetone, Cy=cyclohexyl). This method is highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-02, Vol.45 (8), p.1282-1284
Hauptverfasser: Kudo, Noriaki, Perseghini, Mauro, Fu, Gregory C.
Format: Artikel
Sprache:eng
Schlagworte:
cross‐coupling
heterocycles
homogeneous catalysis
nitrogen
palladium
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Zusammenfassung:A wide‐ranging study of Suzuki reactions which use nitrogen‐containing heterocycles is described (see scheme; dba=dibenzylideneacetone, Cy=cyclohexyl). This method is highly versatile (a single procedure was used for all substrates, including boronate esters and trifluoroborates), compatible with a variety of unprotected functionalities (e.g., NH2‐ and OH‐substituted substrates), and efficient even with unactivated aryl chlorides.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503479