Comparison of the Bioactive Conformations of Sialyl LewisX and a Potent Sialyl LewisX Mimic

Comparison of the Bioactive Conformations of Sialyl LewisX and a Potent Sialyl LewisX Mimic

For the rational design of drugs that inhibit the interaction between E‐selectin and sialyl LewisX, structural information on bound inhibitors is required. The bioactive conformation of the potent sialyl LewisX mimic 1 was therefore determined by transfer NOE NMR spectroscopic methods.

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Veröffentlicht in:Angewandte Chemie International Edition 1997-12, Vol.36 (23), p.2603-2607
Hauptverfasser: Jahnke, Wolfgang, Kolb, Hartmuth C., Blommers, Marcel J. J., Magnani, John L., Ernst, Beat
Format: Artikel
Sprache:eng
Schlagworte:
carbohydrates
NMR spectroscopy
sialyl LewisX
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Zusammenfassung:For the rational design of drugs that inhibit the interaction between E‐selectin and sialyl LewisX, structural information on bound inhibitors is required. The bioactive conformation of the potent sialyl LewisX mimic 1 was therefore determined by transfer NOE NMR spectroscopic methods.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199726031