A New Nickel-Catalyzed Cross-Coupling Reaction between sp3 Carbon Centers

A New Nickel-Catalyzed Cross-Coupling Reaction between sp3 Carbon Centers

Polyfunctional dialkylzinc compounds and primary alkyl iodides bearing a remote double bond undergo nickel‐catalyzed cross‐coupling even at −35 °C within a few hours, as shown in the example below. The resulting polyfunctional products are formed in good yield. NMP = N‐methyl‐2‐pyrrolidinone, acac =...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-01, Vol.34 (23-24), p.2723-2725
Hauptverfasser: Devasagayaraj, Arokiasamy, Stüdemann, Thomas, Knochel, Paul
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
alkene complexes
catalysis
cross-coupling
nickel compounds
zinc compounds
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Zusammenfassung:Polyfunctional dialkylzinc compounds and primary alkyl iodides bearing a remote double bond undergo nickel‐catalyzed cross‐coupling even at −35 °C within a few hours, as shown in the example below. The resulting polyfunctional products are formed in good yield. NMP = N‐methyl‐2‐pyrrolidinone, acac = acetylacetonate, Piv = pivaloyl.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199527231