Novel Bimetallic Model System for Cytochrome P450: Effect of Membrane Environment on the Catalytic Oxidation

Novel Bimetallic Model System for Cytochrome P450: Effect of Membrane Environment on the Catalytic Oxidation

A novel membrane‐bound cytochrome P450 mimic (shown schematically below, 1: a RhIII complex, 2: a manganoporphyrin) catalyzes the epoxidation of alkenes with dioxygen. The turnover numbers achieved with this catalyst are in the same range as those obtained with the natural enzyme.

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Veröffentlicht in:Angewandte Chemie International Edition 1995-01, Vol.33 (23-24), p.2468-2470
Hauptverfasser: Schenning, Albertus P. H. J., Hubert, Dominicus H. W., van Esch, Jan H., Feiters, Martinus C., Nolte, Roeland J. M.
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel membrane‐bound cytochrome P450 mimic (shown schematically below, 1: a RhIII complex, 2: a manganoporphyrin) catalyzes the epoxidation of alkenes with dioxygen. The turnover numbers achieved with this catalyst are in the same range as those obtained with the natural enzyme.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199424681