A Convergent Total Synthesis of Calicheamicin γ 1I

A Convergent Total Synthesis of Calicheamicin γ 1I

Ultimate convergence for the total synthesis of calicheamicin γ 1I has been achieved thanks to a remarkable glycosidation between the glycosyl donor 2 and aglycone ent‐1 (see preceeding communication; R = SSMe, ketal‐protected); after glycosidation the natural product is obtained in two steps....

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Veröffentlicht in:Angewandte Chemie International Edition 1994-05, Vol.33 (8), p.858-862
Hauptverfasser: Hitchcock, Stephen A., Boyer, Serge H., Chu-Moyer, Margaret Y., Olson, Steven H., Danishefsky, Samuel J.
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Sprache:eng
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Zusammenfassung:Ultimate convergence for the total synthesis of calicheamicin γ 1I has been achieved thanks to a remarkable glycosidation between the glycosyl donor 2 and aglycone ent‐1 (see preceeding communication; R = SSMe, ketal‐protected); after glycosidation the natural product is obtained in two steps.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199408581