Rücktitelbild: piSTING: A Pocket‐Independent Agonist Based on Multivalency‐Driven STING Oligomerization (Angew. Chem. 38/2024)

Novel pocket‐independent STING‐activating agonists (piSTINGs), which act through multivalency‐driven oligomerization to activate downstream signalling pathways, were developed by Yan‐Mei Li et al. in their Research Article (e202407037). piSTINGs could serve as novel STING agonists for vaccines and combination therapies. STING oligomerization is a useful strategy for the development of a new generation of STING agonists.