Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds

A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3H)‐ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source a...

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Veröffentlicht in:	Advanced synthesis & catalysis 2021-03, Vol.363 (5), p.1417-1426
Hauptverfasser:	Wang, Le‐Cheng, Zhang, Yu, Chen, Zhengkai, Wu, Xiao‐Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	2-(trifluoromethyl)quinazolin-4(3H)-ones Carbon monoxide carbonylation Carbonyls Chemical reduction Chemical synthesis Chemistry Chemistry, Applied Chemistry, Organic Chlorides N-heterocyclic compounds Nitro compounds Palladium Physical Sciences Reagents Science & Technology trifluoroacetimidoyl chlorides
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Zusammenfassung:	A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3H)‐ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.202001502