Synthesis of Coumarins in a Molten n-Bu4NOAc/n-Bu4NBr Mixture through a Domino Heck Reaction/Cyclization Process

Synthesis of Coumarins in a Molten n-Bu4NOAc/n-Bu4NBr Mixture through a Domino Heck Reaction/Cyclization Process

4‐Arylcoumarins can be prepared in good to high yields by reacting readily available methyl or butyl 3‐(o‐hydroxyaryl)acrylates with aryl iodides and bromides in an n‐Bu4NOAc/n‐Bu4NBr mixture at 100 °C in the presence of Pd(OAc)2.

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Veröffentlicht in:Advanced synthesis & catalysis 2005-02, Vol.347 (2-3), p.308-312
Hauptverfasser: Battistuzzi, Gianfranco, Cacchi, Sandro, De Salve, Ilse, Fabrizi, Giancarlo, Parisi, Luca M.
Format: Artikel
Sprache:eng
Schlagworte:
coumarins
cyclization
Heck reaction
ionic liquids
palladium
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Zusammenfassung:4‐Arylcoumarins can be prepared in good to high yields by reacting readily available methyl or butyl 3‐(o‐hydroxyaryl)acrylates with aryl iodides and bromides in an n‐Bu4NOAc/n‐Bu4NBr mixture at 100 °C in the presence of Pd(OAc)2.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200404297