Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

A unique type of pH/H2O2 dual‐responsive intelligent nanoscale delivery system based on albumin‐coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME‐responsive size changes enable effective intratumor diffusion. A highly ef...

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Veröffentlicht in:Advanced materials (Weinheim) 2016-09, Vol.28 (33), p.7129-7136
Hauptverfasser: Chen, Qian, Feng, Liangzhu, Liu, Jingjing, Zhu, Wenwen, Dong, Ziliang, Wu, Yifan, Liu, Zhuang
Format: Artikel
Sprache:eng
Schlagworte:
albumin
combination therapies
deep penetration
manganese dioxide
tumor microenvironment
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Zusammenfassung:A unique type of pH/H2O2 dual‐responsive intelligent nanoscale delivery system based on albumin‐coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME‐responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201601902