Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri-Modality Imaging

Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri-Modality Imaging

Fluorinated polyethylenimine derivative labeled with radionuclide 99mTc is developed as a 19F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)‐targeting ability. This multifunctional agent is safe and suitable for 19F MRI/SPECT/PA imaging and has the potentia...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Weinheim) 2016-07, Vol.28 (28), p.5898-5906
Hauptverfasser: Guo, Zhide, Gao, Mengna, Song, Manli, Li, Yesen, Zhang, Deliang, Xu, Duo, You, Linyi, Wang, Liangliang, Zhuang, Rongqiang, Su, Xinhui, Liu, Ting, Du, Jin, Zhang, Xianzhong
Format: Artikel
Sprache:eng
Schlagworte:
19F magnetic resonance imaging
liver function
molecular imaging
photoacoustic imaging
single-photon-emission computed tomography
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Fluorinated polyethylenimine derivative labeled with radionuclide 99mTc is developed as a 19F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)‐targeting ability. This multifunctional agent is safe and suitable for 19F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201601064