Multifunctional Fe5C2 Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography-Guided Photothermal Therapy

Multifunctional Fe5C2 Nanoparticles: A Targeted Theranostic Platform for Magnetic Resonance Imaging and Photoacoustic Tomography-Guided Photothermal Therapy

Fe5C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342)...

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Veröffentlicht in:Advanced materials (Weinheim) 2014-06, Vol.26 (24), p.4114-4120
Hauptverfasser: Yu, Jing, Yang, Ce, Li, Jingdingsha, Ding, Yichen, Zhang, Lei, Yousaf, Muhammad Zubair, Lin, Jian, Pang, Rui, Wei, Lanbin, Xu, Lili, Sheng, Fugeng, Li, Changhui, Li, Gongjie, Zhao, Lingyun, Hou, Yanglong
Format: Artikel
Sprache:eng
Schlagworte:
iron carbides
magnetic resonance imaging
multifunctional probes
photoacoustic tomography
photothermal therapy
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Zusammenfassung:Fe5C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342), they can target to tumor cells with low cytotoxicity, and kill them through laser irritation. It is also possible to ablate tumors under guidance by MRI and PTT without noticeable side effects.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201305811