Mechanisms of Theta Plasmid Replication

Plasmids have been used as convenient models for the study of molecular mechanisms of replication and DNA repair due to their small size, dispensability to the host, and easy manipulation. In addition, plasmids are key facilitators for the evolution and dissemination of drug resistance and for the evolution of complex interactions with animal or plant hosts. Understanding plasmid replication and maintenance therefore has significant practical implications for the clinic and for bioremediation.