Neural‐Tissue Engineering Interventions for Traumatic Brain Injury

This chapter reviews different current neuro‐tissue engineering approaches that focus on minimizing tissue degeneration and promoting tissue regeneration. Neuro‐tissue engineering not only holds promise in clinical settings such as traumatic brain injury (TBI) but also in scientific settings where biological substitutes may act as in vitro real tissue‐like test systems. The chapter examines the process of neurogenesis in order to fully understand cell‐based therapies. This process covers the relationship between developmental and neural stem cell biology as well as the natural endogenous potential of neural repair by resident neural stem cells. The chapter presents the most recent therapeutic advances in line with the four categories, including cell‐based therapies, biomaterials‐based therapies, application to living system, and transition to the clinic. Cell‐based therapies in the chapter look into the use of different cell types, ranging from adult to embryonic cell sources, to obtain the optimal cellular milieu for regeneration process.