Interaction Kinetic Data Generated by Surface Plasmon Resonance Biosensors and the Use of Kinetic Rate Constants in Lead Generation and Optimization

Interaction Kinetic Data Generated by Surface Plasmon Resonance Biosensors and the Use of Kinetic Rate Constants in Lead Generation and Optimization

This chapter contains sections titled: Background SPR Biosensor Technology From Interaction Models to Kinetic Rate Constants and Affinity Affinity versus Kinetic Rate Constants for Evaluation of Interactions From Models to Mechanisms Structural Information The Use of Kinetic Rate Constants in Lead G...

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Bibliographische Detailangaben
1. Verfasser: Danielson, U. Helena
Format: Buchkapitel
Sprache:eng
Schlagworte:
HIV protease
ligand
nonnucleoside inhibitors
protein kinase
small‐molecule drug discovery
surface plasmon resonance
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Beschreibung
Zusammenfassung:This chapter contains sections titled: Background SPR Biosensor Technology From Interaction Models to Kinetic Rate Constants and Affinity Affinity versus Kinetic Rate Constants for Evaluation of Interactions From Models to Mechanisms Structural Information The Use of Kinetic Rate Constants in Lead Generation and Optimization Designing Compounds with Optimal Properties Conclusions Acknowledgments References
DOI:10.1002/9783527645947.ch4