Detection in Packed Column SFC

This chapter describes the most popular predecompression detectors, along with a few less common, yet interesting, modes of predecompression detection. It devotes to the modes of interfacing the column supercritical fluid chromatography (SFC) column to a postdecompression detector are sufficiently varied to the advantages and limitations of these interfacing approaches. Smith et al. brought the selectivity and sensitivity advantages of fluorescence detection to packed column SFC. Ultraviolet/visible light absorbance is a mainstay of routine SFC applications, especially in quality control operations. Detection was performed on column, thereby avoiding the requirement of using a fluorescence detector with a high‐pressure flow cell. Flame‐based detectors are widely used in gas chromatography. The flame ionization detector (FID) is the flagship among these.