Common germline polymorphisms associated with breast cancer-specific survival

Common germline polymorphisms associated with breast cancer-specific survival

Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-sp...

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Hauptverfasser: Kraft, P, Canisius, S, Rahman, N, Nevanlinna, H, Bolla, M.K, Wang, Q, Dennis, J, Lush, M, Dunning, A.M, Czene, K, Lambrechts, D, Leunen, K, van Ongeval, C, Nordestgaard, B.G, Nielsen, S.F, Rudolph, A, Seibold, P, Blomqvist, C, Fagerholm, R, Muranen, T.A, Olsen, J.E, Vachon, C, Knight, J.A, Glendon, G, Mulligan, A.M, Broeks, A, Haiman, C.A, Henderson, B.E, Schumacher, F, Hopper, J.L, Tsimiklis, H, Apicella, C, Southey, M.C, Cross, S.S, Reed, M.W.R, Giles, G.G, Milne, R.L, Winqvist, R, Jukkola-Vuorinen, A, Grip, M, Hollestelle, A, Martens, J.W.M, van den Ouweland, A.M.W, Schneeweiss, A, Burwinkel, B, Figueroa, J, Chanock, S.J, Sawyer, E.J, Kerin, M.J, Miller, N, Brenner, H, Holleczek, B, Kataja, V, Kosma, V-M, Hartikainen, J.M, Li, J, Humphreys, K, Devilee, P, Tollenaar, R.A.E.M, Seynaeve, C, Radice, P, Beckmann, M.W, Hein, A, Ekici, A.B, Balleine, R, Benitez, J, Zamora, M.P, Perez, J.I.A, Jakubowska, A, Hamann, U, Ulmer, H.U, Ruediger, T, Margolin, S, Kristensen, V, Abraham, J, Earl, H, Hiller, L, Dunn, J.A, Campa, D, Diver, W.R, Gaudet, M.M, Hankinson, S, Hoover, R.N, Kaaks, R, Chin, S-F, Caldas, C, Hunter, D.J, Lindstrom, S, Garcia-Closas, M, Couch, F.J, Investigators, kConFab, Chenevix-Trench, G, Mannermaa, A, Andrulis, I.L, Chang-Claude, J, Easton, D.F, Bojesen, S.E, Cox, A, Fasching, P.A, Schmidt, M.K
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Sprache:eng
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Zusammenfassung:Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value
DOI:10.1186/s13058-015-0570-7