Potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment

Potential application of PS-OCT in the safety assessment of non-steroidal topical creams for atopic dermatitis treatment

Crisaborole 2% ointment is a non-steroidal treatment for mild-moderate atopic dermatitis (AD) and may produce fewer adverse effects than topical corticosteroids (TCS). We used PS-OCT to quantify dermal collagen at baseline and after 29 days of treatment with crisaborole and betamethasone valerate (B...

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Hauptverfasser: Duan, M.Q, Byers, R.A, Danby, S.G, Sahib, S, Cha, A, Zang, C, Werth, J, Adiri, R, Taylor, R.N, Cork, M.J, Matcher, S.J
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Sprache:eng
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Zusammenfassung:Crisaborole 2% ointment is a non-steroidal treatment for mild-moderate atopic dermatitis (AD) and may produce fewer adverse effects than topical corticosteroids (TCS). We used PS-OCT to quantify dermal collagen at baseline and after 29 days of treatment with crisaborole and betamethasone valerate (BMV), in 32 subjects. PS-OCT detected a mean increase 1 × 10-6, 95% CI (6.3, 1.37) × 10-6 in dermal birefringence following TCS use (p 
DOI:10.1364/boe.494464