Denitrative Hydroxylation of Unactivated Nitroarenes
A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and compu...
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| Format: | Artikel |
| Sprache: | eng |
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| Zusammenfassung: | A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism. |
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| DOI: | 10.1002/chem.202203807 |