Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is asses...

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Hauptverfasser: Abdelaziz, A, Aldridge, J, Al-Hakim, B, Al-Khalil, M, Anand, A, Balmforth, C, Bambridge, G, Beak, P, Beckitt, R, Begum, A, Bell, JL, BinRofaie, M, Borbone, J, Bottrill, F, Bray, N, Broadley, A, Bukhari, M, Buttress, D, Cameron, F, Caplin, B, Chadwick, R, Christopherson, T, Cousins, R, Daoud, N, Dela Rosa, A, Diwakar, L, Dowling, S, Dunn, P, Duric, N, Edmonds, J, Edwards, A, Fenn, A, Field, B, Fowler, E, Fuller, B, Galloway, J, Gordon, S, Gray, N, Green, M, Gregory, K, Griffin, M, Groves, J, Gunawardena, M, Harin, A, Haroon, MA, Hayman, A, Hikmat, M, Holt, S, Hughes, G, James, L, Janmohamed, A, Jarvie, E, Kamath, A, Khurana, C, Kirwan, U, Kislingbury, K, Koirata, A, Lawson, L, Levett, C, Mackay, E, Mahaveer, A, Maheswaran, T, Marchand, C, McDevitt, K, McGoldrick, C, McSkeane, A, Mercioniu, M, Morley, A, Moss, S, Murray, L, Nisbett, T, O'Brien, N, Oleszkiewicz, G, Osborne, L, Parker, J, Pereira, A, Periyasamy, L, Potla, P, Proctor, C, Quigley, J, Razvi, Z, Ross-Parker, A, Rudran, B, Rughani, P, Sana, I, Scholes, K, Skinner, D, Srinivasan, R, Tahir, H, Taylor, C, Thet, P, Thorne, N, Tomasova, N, Ur Rasool, M, Victor, S, Ward, J, Warren, J, Williams, G, Woolf, R, Zmierczak, A
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Zusammenfassung:Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation
DOI:10.1016/s0140-6736(21)00676-0