DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epigenome-wide association study on 611 adults free of...

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Hauptverfasser: Georgiadis, P, Gavriil, M, Rantakokko, P, Ladoukakis, E, Botsivali, M, Kelly, RS, Bergdahl, IA, Kiviranta, H, Vermeulen, RCH, Spaeth, F, Hebbels, DGAJ, Kleinjans, JCS, de Kok, TMCM, Palli, D, Vineis, P, Kyrtopoulos, SA, Gottschalk, R, van Leeuwen, D, Timmermans, L, Bendinelli, B, Portengen, L, Saberi-Hosnijeh, F, Melin, B, Hallmans, G, Lenner, P, Keun, HC, Siskos, A, Athersuch, TJ, Kogevinas, M, Stephanou, EG, Myridakis, A, Fazzo, L, De Santis, M, Comba, P, Airaksinen, R, Ruokojärvi, P, Gilthorpe, M, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chen, WJ, Lee, W-C, Hsiao, CK, Chien, K-L, Kuo, P-H, Hung, H, Liao, S-F, EnviroGenomarkers consortium
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Sprache:eng
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Zusammenfassung:Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epigenome-wide association study on 611 adults free of diagnosed disease, living in Italy and Sweden, in whom we also measured plasma concentrations of 6 PCB congeners, DDE and hexachlorobenzene. Results: We identified 650 CpG sites whose methylation correlates strongly (FDR 
DOI:10.1016/j.envint.2019.01.068