Genetic susceptibility to radiation-induced breast cancer after Hodgkin Lymphoma

Genetic susceptibility to radiation-induced breast cancer after Hodgkin Lymphoma

Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211,155 germline single nucleotide polymorphisms (SNPs) for gene-radiation interaction on breast cance...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Opstal-van Winden, A.W.J, de Haan, H.G, Hauptmann, M, Schmidt, M.K, Broeks, A, Russell, N.S, Janus, C.P.M, Krol, A.D.G, van der Baan, F.H, De Bruin, M.L, van Eggermond, A.M, Dennis, J, Anton Culver, H, Haiman, C.A, Sawyer, E.J, Cox, A, Devilee, P, Hooning, M.J, Peto, J, Couch, F.J, Pharoah, P, Orr, N, Easton, D.F, Aleman, B.M.P, Strong, L.C, Bhatia, S, Cooke, R, Robison, L.L, Swerdlow, A.J, van Leeuwen, F.E
Format: Artikel
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211,155 germline single nucleotide polymorphisms (SNPs) for gene-radiation interaction on breast cancer risk in a case-only analysis including 327 breast cancer patients after chest RT for HL and 4,671 first primary breast cancer patients. Nine SNPs showed statistically significant interaction with RT on breast cancer risk (false discovery rate
DOI:10.1182/blood-2018-07-862607