DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known...

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Hauptverfasser: Perry, J.R.B, Hsu, Y-H, Chasman, D.I, Johnson, A.D, Elks, C, Albrecht, E, Andrulis, I.L, Beesley, J, Berenson, G.S, Bergmann, S, Bojesen, S.E, Bolla, M.K, Brown, J, Buring, J.E, Campbell, H, Chang-Claude, J, Chenevix-Trench, G, Corre, T, Couch, F.J, Cox, A, Czene, K, D'adamo, A.P, Davies, G, Deary, I.J, Dennis, J, Easton, D.F, Engelhardt, E.G, Eriksson, J.G, Esko, T, Fasching, P.A, Figueroa, J.D, Flyger, H, Fraser, A, Garcia-Closas, M, Gasparini, P, Gieger, C, Giles, G, Guenel, P, Haegg, S, Hall, P, Hayward, C, Hopper, J, Ingelsson, E, Kardia, L.R, Kasiman, K, Knight, J.A, Lahti, J, Lawlor, D.A, Magnusson, P.K.E, Margolin, S, Marsh, J.A, Metspalu, A, Olson, J.E, Pennell, C.E, Polasek, O, Rahman, I, Ridker, P.M, Robino, A, Rudan, I, Rudolph, A, Salumets, A, Schmidt, M.K, Schoemaker, M.J, Smith, E.N, Smith, J.A, Southey, M, Stoeckl, D, Swerdlow, A.J, Thompson, D.J, Truong, T, Ulivi, S, Waldenberger, M, Wang, Q, Wild, S, Wilson, J.F, Wright, A.F, Zgaga, L, Ong, K.K, Murabito, J.M, Karasik, D, Murray, A, Investigators, K, Consortium, R
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Zusammenfassung:The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain
DOI:10.1093/hmg/ddt620